Welcome to the Zhang Lab
Single-Cell Data-Driven Computational Omics and Systems Immunology (COSI)
We develop computational AI and machine learning methods for single-cell omics to study inflammatory disease for translational medicine in the Dept. of Medicine Division of Rheumatology and Dept. of Biomedical Informatics Center for Health Artificial Intelligence, the University of Colorado Anschutz Medical Campus.
Recent lab news
💰 2026 July - Thrilled to share that we received the NIAID P01 multi-project grant, with Fan serving as a Project Lead: “Microbial Drivers and Pathogenic Mechanisms in Rheumatoid Arthritis Natural History”. Dr. Holers is the contact PI, along with outstanding collaborators including Drs. Kuhn and Buckner.
👏🏻 2026 April - The YouTube video for the Department of Medicine Grand Rounds | Fan Zhang & Helena Jonsson is now available to watch!
📚 2026 April - Congrats Vanderlinden, L., et al on on manuscript, preprint bioRxiv, https://www.biorxiv.org/content/10.64898/2026.05.04.722712v2
💰 2025 Aug - Thrilled 🎉 to share that Fan has been awarded a five-year NIH R01! This link is the School of Medicine news feature on this!
Our Science
🖥 We develop novel AI and machine learning methods for single-cell omics
Reynoso, et al., Briefings in Bioinformatics, 2025
Young, et al, Advanced Science, 2025
Guo, et al, Bioinformatics Advances, 2024
🧬 We decipher pathogenic mechanisms for immune-mediated diseases
Inamo, et al,JCI, 2025
Zhang*, Wei*, Slowikowski*, Fonseka*, Rao*, et al, Nature Immunology, 2019
💊 We integrate cross-disease cross-cohort data to uncover novel biomarkers for translational medicine
Zhang*, Jonsson*, et al, Nature, 2023
Jonsson*, Zhang*, et al, Science Translational Medicine, 2022
Zhang, et al. Genome Medicine, 2021
