Welcome to the Zhang Lab
Single-Cell Data-Driven Computational Omics and Systems Immunology (COSI)
We develop computational machine learning methods for single-cell omics to study inflammatory disease for translational medicine in Dept. of Medicine Division of Rheumatology and Dept. of Biomedical Informatics Center for Health Artificial Intelligence, the University of Colorado Anschutz Medical Campus.
Recent lab news
👏🏻 2026 April - Welcome Shunsuke Uchiyama to the lab as a Postdoc Fellow!
📚 2026 April - Congrats Vanderlinden, L., et al on on manuscript, preprint bioRxiv, https://www.biorxiv.org/content/10.64898/2026.05.04.722712v2
📚 2026 Feb - Congrats Inamo, J., et al on manuscript! Check out preprint medRxiv, https://doi.org/10.64898/2026.02.12.26346058!
💰 2025 Aug - Thrilled 🎉 to share that Fan has been awarded a five-year NIH R01! This link is the School of Medicine news feature on this!
Our Science
🖥 We develop novel computational machine learning methods for single-cell omics
Reynoso, et al., Briefings in Bioinformatics, 2025
Young, et al, Advanced Science, 2025
Guo, et al, Bioinformatics Advances, 2024
🧬 We decipher pathogenic immune molecular mechanisms for immune-mediated diseases
Inamo, et al, JCI, 2025
Zhang*, Wei*, Slowikowski*, Fonseka*, Rao*, et al, Nature Immunology, 2019
💊 We integrate cross-disease cross-cohort data to uncover novel phenotypes for translational medicine
Zhang*, Jonsson*, et al, Nature, 2023
Jonsson*, Zhang*, et al, Science Translational Medicine, 2022
Zhang, et al. Genome Medicine, 2021
